Masses and age of the Chemically Peculiar double-lined binary χ\chi~Lupi

We aim at measuring the stellar parameters of the two Chemically Peculiar components of the B9.5Vp HgMn + A2 Vm double-lined spectroscopic binary HD141556, whose period is 15.25 days. We combined historical radial velocity measurements with new spatially resolved astrometric observations from PIONIER/VLTI to reconstruct the three-dimensional orbit of the binary, and thus obtained the individual masses. We fit the available photometric points together with the flux ratios provided by interferometry to constrain the individual sizes, which we compared to predictions from evolutionary models.The individual masses of the components are \Ma = 2.84 \pm 0.12\ \Msun and \Mb = 1.94 \pm 0.09\ \Msun. The dynamical distance is compatible with the Hipparcos parallax. We find linear stellar radii of \Ra=2.85 \pm 0.15\ \Rsun and \Rb=1.75 \pm 0.18\ \Rsun. This result validates a posteriori the flux ratio used in previous detailed abundance studies. We determine a sub-solar initial metallicity $Z=0.012\pm0.003$ and an age of $(2.8\pm0.3)\times10^8\$years. Our results imply that the primary rotates more slowly than its synchronous velocity, while the secondary is probably synchronous. We show that strong tidal coupling during the pre-main sequence evolution followed by a full decoupling at zero-age main sequence provides a plausible explanation for these very low rotation rates.Comment: 8 pages, accepted in Aand

An Examination of the Hidden Judging Criteria in the Generative Design in Minecraft Competition

© 2023 IEEE. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1109/TG.2023.3329763Game content has long been created using procedural generation. However, many of these systems are currently designed in an ad-hoc manner, and there is a lack of knowledge around the design criteria that lead to generators producing the most successful results. In this study, we conduct a qualitative examination of the comments left by judges for the 2018--2020 \textit{Generative Design in Minecraft} competition. Using abductive thematic analysis, we identify the core design criteria that contribute to a generator that creates ``good'' content -- here defined as interesting or engaging. By performing this study, we have identified that the core design criteria that create and interesting settlement are usability of the settlement environment, the thematic coherence within the settlement, and an anchoring in real-world simulacra.Peer reviewe

Seasonal Variation of Thermocline Depth: Consequence on Nutrient Availability in the Ivorian Coastal Zone

Faced with the threat of overfishing in Africa, this study was initiated in the coastal zone of Côte d'Ivoire to understand the nutrients availability as function of variation in the depth of thermocline. Data from the ocean bank, World Ocean Atlas (WOA), were used in the ODV software during the twelve months of 2009 taken at 5.5°W/4.5°N (station coordinates). ODV software has allowed to make seasonal analysis, from vertical profiles and latitudinal analysis from the coast toward the sea through some parameters such as temperature, nitrate, phosphate and oxygen. The depth of thermocline, nitracline, phosphacline and oxycline was determined by the seasonal analysis. To evaluate the enrichment intensity of coast towards the sea, latitudinal analysis was investigated using the section profiles (1°S/5°N coordinates). The main results have shown not only the variation in the depth of the thermocline, but also the variation of nitracline, phosphacline and oxycline at different marine seasons. During the cold season, there was an ascent of the thermocline over the surface of water and a strong enrichment from the coast to the sea especially in August. While in hot season, the thermocline was lower and its stability has favoured the stratification of the water column, which prevents the enrichment of the oxygenated surface layer. Analysis of relationships shows that nutrient elements and oxygen change polynomially with temperature

Vocabulaire 3D - Lexique pour les Sciences Humaines et Sociales

Ce document est le résultat d’un effort continu pour permettre aux acteurs des SHS et ceux de la 3D d’interagir autour d’un vocabulaire commun. Ce lexique a pour but d’accompagner les différents livrables du consortium 3D. Il a aussi vocation à terme à aider à l’enrichissement de TaDiRAH , « Taxonomy of Digital Research Activities in the Humani-ties » du consortium européen DARIAH . Ce processus continu est illustré par le fait que ce document en est à sa deuxième versionCe document est le résultat d’un effort continu pour permettre aux acteurs des SHS et ceux de la 3D d’interagir autour d’un vocabulaire commun. Ce lexique a pour but d’accompagner les différents livrables du consortium 3D. Il a aussi vocation à terme à aider à l’enrichissement de TaDiRAH , « Taxonomy of Digital Research Activities in the Humani-ties » du consortium européen DARIAH . Ce processus continu est illustré par le fait que ce document en est à sa deuxième versio

Proposal of a framework for evaluating military surveillance systems for early detection of outbreaks on duty areas

<p>Abstract</p> <p>Background</p> <p>In recent years a wide variety of epidemiological surveillance systems have been developed to provide early identification of outbreaks of infectious disease. Each system has had its own strengths and weaknesses. In 2002 a Working Group of the Centers for Disease Control and Prevention (CDC) produced a framework for evaluation, which proved suitable for many public health surveillance systems. However this did not easily adapt to the military setting, where by necessity a variety of different parameters are assessed, different constraints placed on the systems, and different objectives required. This paper describes a proposed framework for evaluation of military syndromic surveillance systems designed to detect outbreaks of disease on operational deployments.</p> <p>Methods</p> <p>The new framework described in this paper was developed from the cumulative experience of British and French military syndromic surveillance systems. The methods included a general assessment framework (CDC), followed by more specific methods of conducting evaluation. These included Knowledge/Attitude/Practice surveys (KAP surveys), technical audits, ergonomic studies, simulations and multi-national exercises. A variety of military constraints required integration into the evaluation. Examples of these include the variability of geographical conditions in the field, deployment to areas without prior knowledge of naturally-occurring disease patterns, the differences in field sanitation between locations and over the length of deployment, the mobility of military forces, turnover of personnel, continuity of surveillance across different locations, integration with surveillance systems from other nations working alongside each other, compatibility with non-medical information systems, and security.</p> <p>Results</p> <p>A framework for evaluation has been developed that can be used for military surveillance systems in a staged manner consisting of initial, intermediate and final evaluations. For each stage of the process parameters for assessment have been defined and methods identified.</p> <p>Conclusion</p> <p>The combined experiences of French and British syndromic surveillance systems developed for use in deployed military forces has allowed the development of a specific evaluation framework. The tool is suitable for use by all nations who wish to evaluate syndromic surveillance in their own military forces. It could also be useful for civilian mobile systems or for national security surveillance systems.</p

EBioMedicine

Background High HIV-1 DNA levels in peripheral blood mononuclear cells (PBMC) were associated with a higher risk of severe morbidity and a faster decline in CD4 count in ART-naive patients. We report the association between HIV-1 DNA and mortality in HIV-infected adults in a trial of early ART in West Africa. Methods In the Temprano trial, HIV-infected adults were randomly assigned to start ART immediately or defer ART. After trial termination, HIV-1 DNA was measured in whole blood samples frozen at baseline. We analyzed the association between baseline PBMC HIV-1 DNA and long-term mortality

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Proceedings of Abstracts, School of Physics, Engineering and Computer Science Research Conference 2022

© 2022 The Author(s). This is an open-access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For further details please see https://creativecommons.org/licenses/by/4.0/. Plenary by Prof. Timothy Foat, ‘Indoor dispersion at Dstl and its recent application to COVID-19 transmission’ is © Crown copyright (2022), Dstl. This material is licensed under the terms of the Open Government Licence except where otherwise stated. To view this licence, visit http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: [email protected] present proceedings record the abstracts submitted and accepted for presentation at SPECS 2022, the second edition of the School of Physics, Engineering and Computer Science Research Conference that took place online, the 12th April 2022